The Protective Function of Neutrophil Elastase Inhibitor in Liver Ischemia/Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
neutrophil elastase inhibitor following liver resection: a matched cohort study
background sivelestat is a neutrophil elastase inhibitor (nei) with positive impact on the respiratory complications in thoracic surgery. based on the findings of a recent study, nei may have a good response for avoiding ischemia reperfusion injury in liver resection. conclusions intravenous nei administration had positive impact on the postoperative inflammatory response and oxygenation while ...
متن کاملProtective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury
Neutrophils play an important part in the development of acute inflammatory injury. Human neutrophils contain high levels of the serine protease elastase, which is stored in azurophilic granules and is secreted in response to inflammatory stimuli. Elastase is capable of degrading many components of extracellular matrix [1-4] and has cytotoxic effects on endothelial cells [5-7] and airway epithe...
متن کاملNeutrophil Elastase Inhibitor Following Liver Resection: A Matched Cohort Study.
BACKGROUND Sivelestat is a neutrophil elastase inhibitor (NEI) with positive impact on the respiratory complications in thoracic surgery. Based on the findings of a recent study, NEI may have a good response for avoiding ischemia reperfusion injury in liver resection. OBJECTIVES The current study aimed to examine the impact of NEI on the postoperative outcomes after liver resection. PATIENT...
متن کاملThe use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy
BACKGROUND The prognosis of acute lung injury (ALI) after pneumonectomy is poor, with reported mortality rates of 30-100%. Neutrophil elastase inhibitor (NEI) is known to prevent lung injury caused by neutrophil elastase and improve lung function in ALI. We evaluated the effect of NEI on ALI after pneumonectomy. METHODS We analyzed nine patients who required ventilator care due to ALI after p...
متن کاملThe neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats
Sepsis-induced acute kidney injury (AKI) represents a major cause of mortality in intensive care units. Sivelestat, a selective inhibitor of neutrophil elastase (NE), can attenuate sepsis-related acute lung injury. However, whether sivelestat can preserve kidney function during sepsis remains unclear. In this study, we thus examined the effects of sivelestat on sepsis-related AKI. Cecal ligatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transplantation
سال: 2010
ISSN: 0041-1337
DOI: 10.1097/tp.0b013e3181d45a98